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Oral Bacteria's Impact on Disease

Studies reveal oral bacteria's role in conditions like diabetes and heart disease.

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Atarashi, K., Suda, W., Luo, C., Kawaguchi, T., Motoo, I., Narushima, S., et al. (2017). Ectopic colonization of oral bacteria in the intestine drives T H 1 cell induction and inflammation. Science 358, 359–365. doi: 10.1126/science.aan4526
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Bazzani, D., Heidrich, V., Manghi, P., Blanco-Miguez, A., Asnicar, F., Armanini, F., et al. (2024). Favorable subgingival plaque microbiome shifts are associated with clinical treatment for peri-implant diseases. Npj Biofilms Microbiomes 10, 12. doi: 10.1038/s41522-024-00482-z
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Belibasakis, G. N., and Manoil, D. (2021). Microbial Community-Driven Etiopathogenesis of Peri-Implantitis. J. Dent. Res. 100, 21–28. doi: 10.1177/0022034520949851
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Bourgeois, D., Inquimbert, C., Ottolenghi, L., and Carrouel, F. (2019). Periodontal Pathogens as Risk Factors of Cardiovascular Diseases, Diabetes, Rheumatoid Arthritis, Cancer, and Chronic Obstructive Pulmonary Disease—Is There Cause for Consideration? Microorganisms 7, 424. doi: 10.3390/microorganisms7100424
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Butera, A., Pascadopoli, M., Pellegrini, M., Gallo, S., Zampetti, P., and Scribante, A. (2022). Oral Microbiota in Patients with Peri-Implant Disease: A Narrative Review. Appl. Sci. 12, 3250. doi: 10.3390/app12073250
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Di Stefano, M., Polizzi, A., Santonocito, S., Romano, A., Lombardi, T., and Isola, G. (2022). Impact of Oral Microbiome in Periodontal Health and Periodontitis: A Critical Review on Prevention and Treatment. Int. J. Mol. Sci. 23, 5142. doi: 10.3390/ijms23095142
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Gao, L., Xu, T., Huang, G., Jiang, S., Gu, Y., and Chen, F. (2018). Oral microbiomes: more and more importance in oral cavity and whole body. Protein Cell 9, 488–500. doi: 10.1007/s13238-018-0548-1
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Hajishengallis, G., Liang, S., Payne, M. A., Hashim, A., Jotwani, R., Eskan, M. A., et al. (2011). Low-Abundance Biofilm Species Orchestrates Inflammatory Periodontal Disease through the Commensal Microbiota and Complement. Cell Host Microbe 10, 497–506. doi: 10.1016/j.chom.2011.10.006
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Hitchon, C. A., Chandad, F., Ferucci, E. D., Willemze, A., Ioan-Facsinay, A., Woude, D. van der, et al. (2010). Antibodies to Porphyromonas gingivalis Are Associated with Anticitrullinated Protein Antibodies in Patients with Rheumatoid Arthritis and Their Relatives. J. Rheumatol. 37, 1105–1112. doi: 10.3899/jrheum.091323
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Hobbins, S., Chapple, I. L., Sapey, E., and Stockley, R. A. (2017). Is periodontitis a comorbidity of COPD or can associations be explained by shared risk factors/behaviors? Int. J. Chron. Obstruct. Pulmon. Dis. 12, 1339–1349. doi: 10.2147/COPD.S127802
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Lee, Y.-H., Chung, S. W., Auh, Q.-S., Hong, S.-J., Lee, Y.-A., Jung, J., et al. (2021). Progress in Oral Microbiome Related to Oral and Systemic Diseases: An Update. Diagnostics 11, 1283. doi: 10.3390/diagnostics11071283
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Li, R., Tian, C., Postlethwaite, A., Jiao, Y., Garcia-Godoy, F., Pattanaik, D., et al. (2017). Rheumatoid arthritis and periodontal disease: What are the similarities and differences? Int. J. Rheum. Dis. 20, 1887–1901. doi: 10.1111/1756-185X.13240
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Martini, A. M., Moricz, B. S., Ripperger, A. K., Tran, P. M., Sharp, M. E., Forsythe, A. N., et al. (2020). Association of Novel Streptococcus sanguinis Virulence Factors With Pathogenesis in a Native Valve Infective Endocarditis Model. Front. Microbiol. 11. doi: 10.3389/fmicb.2020.00010
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Peters, B. A., Wu, J., Pei, Z., Yang, L., Purdue, M. P., Freedman, N. D., et al. (2017). Oral Microbiome Composition Reflects Prospective Risk for Esophageal Cancers. Cancer Res. 77, 6777–6787. doi: 10.1158/0008-5472.CAN-17-1296
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Ye, C., and Kapila, Y. (2021). Oral microbiome shifts during pregnancy and adverse pregnancy outcomes: Hormonal and Immunologic changes at play. Periodontol. 2000 87, 276–281. doi: 10.1111/prd.12386
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Graves, D. T., Ding, Z., and Yang, Y. (2020). The impact of diabetes on periodontal diseases. Periodontol. 2000 82, 214–224. doi: 10.1111/prd.12318
Kong J, Liu Y, Qian M, Xing L, Gao S. The relationship between Porphyromonas gingivalis and oesophageal squamous cell carcinoma: a literature review. Epidemiol Infect. 2023 Apr 3;151:e69. doi: 10.1017/S0950268823000298. PMID: 37009715; PMCID: PMC10204138.